8-Nitroquinoline

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4-Nitroquinoline 1-oxide forms 8-hydroxydeoxyguanosine in human fibroblasts through reactive oxygen species.

4-Nitroquinoline 1-oxide (4NQO) is thought to elicit its carcinogenicity by producing DNA adducts after being metabolized to 4-hydroxyaminoquinoline 1-oxide, which forms 8-hydroxydeoxyguanosine (8OHdG), oxidative damage. To determine whether reactive oxygen species (ROS) are involved in the generation of 8OHdG by 4NQO, we used high-performance liquid chromatography and immunohistochemistry to m...

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Effects of 4-nitroquinoline-N-oxide on RNA synthesis.

rearrangement of the nucleolonema and pars amorpha of the nucleolus. In addition to being carcinogenic, 4-nitroquinoline-N-oxide and several of its derivatives have been shown to be potent mutagenic agents (18). Thus, 4-nitroquinoline-N-oxide has been reported to exert mutagenic effects in bacterial systems and in viruses (4). Yeast cells (18) after exposure to 4-nitro quinoline-N-oxide gave ri...

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Effect of common agonists on cytoplasmic ionized calcium concentration in platelets. Measurement with 2-methyl-6-methoxy 8-nitroquinoline (quin2) and aequorin.

Because of controversy regarding the relationship of cytoplasmic ionized calcium concentration ([Cai2+]) to platelet activation, we studied the correlation of platelet aggregation and ATP secretion with [Cai2+] as determined by 2-methyl-6-methoxy 8-nitroquinoline (quin2) and aequorin in response to ADP, epinephrine, collagen, the Ca2+ ionophore A23187, and thrombin. Both indicators showed a con...

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Alteration of cell-mediated immunity in the mouse following administration of 4-nitroquinoline 1-oxide.

The effect of 4-nitroquinoline 1-oxide on the cell-mediated immune response was tested in C57BL/6 female mice. The carcinogen was administered s.c. either 30 days before or just prior to grafting the female recipients with C57BL/6 male skin. Skin graft survival times were noticeably prolonged in mice that received the carcinogen 30 days before grafting. Administration of 4-nitroquinoline 1-oxid...

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Garlic exerts hepatoprotective effects during 4-nitroquinoline 1-oxide-induced oral carcinogenesis in rats.

The modifying effects of garlic (Allium sativum Linn.) on hepatic lipid peroxidation and antioxidant status during 4-nitroquinoline 1-oxide (4NQO)-induced oral carcinogenesis were investigated in male Wistar rats. Enhanced lipid peroxidation in the liver of tumour-bearing animals was accompanied by significant decreases in the activities of glutathione peroxidase (GPx), glutathione S-transferas...

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ژورنال

عنوان ژورنال: Acta Crystallographica Section E Structure Reports Online

سال: 2011

ISSN: 1600-5368

DOI: 10.1107/s1600536811010014